Nonalcoholic fatty liver disease: Diagnostic biomarkers

نویسندگان

  • Fatemeh Hadizadeh
  • Elham Faghihimani
  • Peyman Adibi
چکیده

Nonalcoholic fatty liver disease is a common medical condition worldwide and its prevalence has increased notably in the past few years due to the increases in prevalence of obesity and metabolic syndrome. However, diagnosis of this disease is still a matter of debate because of disease variations and pathophysiologic alterations. Specific single markers have gained considerable attention recently, among them markers related to hepatic pathophysiology, inflammation, adipocytokines and so forth. But, it seems that no single marker is sufficient for diagnosis and staging of the disease, and applying a panel including different types of tests may be more useful.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis and lipid profiles in the liver of rats with nonalcoholic fatty liver disease

Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders. In this study, effect of resveratrol supplementation alone or in combination with interval and continuous exercises was considered on hepatic cells apoptosis and serum lipid profiles in rats with NAFLD. Materials and Methods: Old rats were divided into two groups, including control and NAF...

متن کامل

Noninvasive diagnosis of pediatric nonalcoholic fatty liver disease

Because nonalcoholic steatohepatitis can progress towards cirrhosis even in children, early detection of hepatic fibrosis and accurate diagnosis of nonalcoholic fatty liver disease (NAFLD) are important. Although liver biopsy is regarded as the gold standard of diagnosis, its clinical application is somewhat limited in children due to its invasiveness. Noninvasive diagnostic methods, including ...

متن کامل

Endpoints and clinical trial design for nonalcoholic steatohepatitis.

UNLABELLED Nonalcoholic fatty liver disease is a common cause of chronic liver disease in the general population. Nonalcoholic steatohepatitis (NASH), the aggressive form of nonalcoholic fatty liver disease, is associated with an increased risk of liver-related mortality and cardiovascular disease. At present, a liver biopsy is the only generally acceptable method for the diagnosis of NASH and ...

متن کامل

Nonalcoholic Steatohepatitis: Diagnostic Challenges.

This article reviews diagnostic criteria for nonalcoholic steatohepatitis (NASH), current grading and staging methodology, and diagnostic challenges and pitfalls in routine practice. Current practice guidelines and prognostic and treatment considerations are discussed. The clinical diagnosis of nonalcoholic fatty liver disease may represent stable disease without progressive liver damage, in th...

متن کامل

بررسی اثر سیلی‌مارین بر کبد چرب غیر الکلی کودکان: کارآزمایی بالینی متقاطع

Background and purpose: Nonalcoholic fatty liver disease is one of the most common causes of chronic liver disease and is a major public health problem worldwide. In recent years, the prevalence of nonalcoholic fatty liver disease has increased in children and adolescents. This study aimed to investigate the effect of silymarin on children with nonalcoholic fatty liver disease. Materials and...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2017